ParkinsonCanadaV1, Main, Exploration, bibRecord, 000A86

Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease.

Identifieur interne : 000A86 ( Main/Exploration ); précédent : 000A85; suivant : 000A87

Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease.

Auteurs : Andrew Vo [Canada] ; Nole M. Hiebert [Canada] ; Ken N. Seergobin [Canada] ; Stephanie Solcz [Canada] ; Allison Partridge [Canada] ; Penny A. Macdonald [Canada]

Source :

Frontiers in human neuroscience ; 2014.

RBID : pubmed:25324767

Abstract

Cognitive dysfunction is a feature of Parkinson's Disease (PD). Some cognitive functions are impaired by dopaminergic medications prescribed to address the movement symptoms that typify PD. Learning appears to be the cognitive function most frequently worsened by dopaminergic therapy. However, this result could reflect either impairments in learning (i.e., acquisition of associations among stimuli, responses, and outcomes) or deficits in performance based on learning (e.g., selecting responses). We sought to clarify the specific effects of dopaminergic medication on (a) stimulus-response association learning from outcome feedback and (b) response selection based on learning, in PD. We tested 28 PD patients on and/or off dopaminergic medication along with 32 healthy, age- and education-matched controls. In Session 1, participants learned to associate abstract images with specific key-press responses through trial and error via outcome feedback. In Session 2, participants provided specific responses to abstract images learned in Session 1, without feedback, precluding new feedback-based learning. By separating Sessions 1 and 2 by 24 h, we could distinguish the effect of dopaminergic medication on (a) feedback-based learning and response selection processes in Session 1 as well as on (b) response selection processes when feedback-based learning could not occur in Session 2. Accuracy achieved at the end of Session 1 were comparable across groups. PD patients on medication learned stimulus-response associations more poorly than PD patients off medication and controls. Medication did not influence decision performance in Session 2. We confirm that dopaminergic therapy impairs feedback-based learning in PD, discounting an alternative explanation that warranted consideration.

DOI: 10.3389/fnhum.2014.00784
PubMed: 25324767

Affiliations:

Canada

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease.</title>
<author><name sortKey="Vo, Andrew" sort="Vo, Andrew" uniqKey="Vo A" first="Andrew" last="Vo">Andrew Vo</name>
<affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Psychology, University of Western Ontario London, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Psychology, University of Western Ontario London, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hiebert, Nole M" sort="Hiebert, Nole M" uniqKey="Hiebert N" first="Nole M" last="Hiebert">Nole M. Hiebert</name>
<affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Physiology and Pharmacology, University of Western Ontario London, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Physiology and Pharmacology, University of Western Ontario London, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Seergobin, Ken N" sort="Seergobin, Ken N" uniqKey="Seergobin K" first="Ken N" last="Seergobin">Ken N. Seergobin</name>
<affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>The Brain and Mind Institute, University of Western Ontario London, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Solcz, Stephanie" sort="Solcz, Stephanie" uniqKey="Solcz S" first="Stephanie" last="Solcz">Stephanie Solcz</name>
<affiliation wicri:level="1"><nlm:affiliation>Schulich School of Medicine and Dentistry, University of Western Ontario London, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Schulich School of Medicine and Dentistry, University of Western Ontario London, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Partridge, Allison" sort="Partridge, Allison" uniqKey="Partridge A" first="Allison" last="Partridge">Allison Partridge</name>
<affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>The Brain and Mind Institute, University of Western Ontario London, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Macdonald, Penny A" sort="Macdonald, Penny A" uniqKey="Macdonald P" first="Penny A" last="Macdonald">Penny A. Macdonald</name>
<affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Psychology, University of Western Ontario London, ON, Canada ; Department of Physiology and Pharmacology, University of Western Ontario London, ON, Canada ; Schulich School of Medicine and Dentistry, University of Western Ontario London, ON, Canada ; Department of Clinical Neurological Sciences, University of Western Ontario London, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Psychology, University of Western Ontario London, ON, Canada ; Department of Physiology and Pharmacology, University of Western Ontario London, ON, Canada ; Schulich School of Medicine and Dentistry, University of Western Ontario London, ON, Canada ; Department of Clinical Neurological Sciences, University of Western Ontario London, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
<idno type="RBID">pubmed:25324767</idno>
<idno type="pmid">25324767</idno>
<idno type="doi">10.3389/fnhum.2014.00784</idno>
<idno type="wicri:Area/PubMed/Corpus">000664</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000664</idno>
<idno type="wicri:Area/PubMed/Curation">000664</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000664</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000664</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000664</idno>
<idno type="wicri:Area/Ncbi/Merge">001942</idno>
<idno type="wicri:Area/Ncbi/Curation">001942</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001942</idno>
<idno type="wicri:Area/Main/Merge">000A90</idno>
<idno type="wicri:Area/Main/Curation">000A86</idno>
<idno type="wicri:Area/Main/Exploration">000A86</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease.</title>
<author><name sortKey="Vo, Andrew" sort="Vo, Andrew" uniqKey="Vo A" first="Andrew" last="Vo">Andrew Vo</name>
<affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Psychology, University of Western Ontario London, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Psychology, University of Western Ontario London, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hiebert, Nole M" sort="Hiebert, Nole M" uniqKey="Hiebert N" first="Nole M" last="Hiebert">Nole M. Hiebert</name>
<affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Physiology and Pharmacology, University of Western Ontario London, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Physiology and Pharmacology, University of Western Ontario London, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Seergobin, Ken N" sort="Seergobin, Ken N" uniqKey="Seergobin K" first="Ken N" last="Seergobin">Ken N. Seergobin</name>
<affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>The Brain and Mind Institute, University of Western Ontario London, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Solcz, Stephanie" sort="Solcz, Stephanie" uniqKey="Solcz S" first="Stephanie" last="Solcz">Stephanie Solcz</name>
<affiliation wicri:level="1"><nlm:affiliation>Schulich School of Medicine and Dentistry, University of Western Ontario London, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Schulich School of Medicine and Dentistry, University of Western Ontario London, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Partridge, Allison" sort="Partridge, Allison" uniqKey="Partridge A" first="Allison" last="Partridge">Allison Partridge</name>
<affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>The Brain and Mind Institute, University of Western Ontario London, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Macdonald, Penny A" sort="Macdonald, Penny A" uniqKey="Macdonald P" first="Penny A" last="Macdonald">Penny A. Macdonald</name>
<affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Psychology, University of Western Ontario London, ON, Canada ; Department of Physiology and Pharmacology, University of Western Ontario London, ON, Canada ; Schulich School of Medicine and Dentistry, University of Western Ontario London, ON, Canada ; Department of Clinical Neurological Sciences, University of Western Ontario London, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Psychology, University of Western Ontario London, ON, Canada ; Department of Physiology and Pharmacology, University of Western Ontario London, ON, Canada ; Schulich School of Medicine and Dentistry, University of Western Ontario London, ON, Canada ; Department of Clinical Neurological Sciences, University of Western Ontario London, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Frontiers in human neuroscience</title>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Cognitive dysfunction is a feature of Parkinson's Disease (PD). Some cognitive functions are impaired by dopaminergic medications prescribed to address the movement symptoms that typify PD. Learning appears to be the cognitive function most frequently worsened by dopaminergic therapy. However, this result could reflect either impairments in learning (i.e., acquisition of associations among stimuli, responses, and outcomes) or deficits in performance based on learning (e.g., selecting responses). We sought to clarify the specific effects of dopaminergic medication on (a) stimulus-response association learning from outcome feedback and (b) response selection based on learning, in PD. We tested 28 PD patients on and/or off dopaminergic medication along with 32 healthy, age- and education-matched controls. In Session 1, participants learned to associate abstract images with specific key-press responses through trial and error via outcome feedback. In Session 2, participants provided specific responses to abstract images learned in Session 1, without feedback, precluding new feedback-based learning. By separating Sessions 1 and 2 by 24 h, we could distinguish the effect of dopaminergic medication on (a) feedback-based learning and response selection processes in Session 1 as well as on (b) response selection processes when feedback-based learning could not occur in Session 2. Accuracy achieved at the end of Session 1 were comparable across groups. PD patients on medication learned stimulus-response associations more poorly than PD patients off medication and controls. Medication did not influence decision performance in Session 2. We confirm that dopaminergic therapy impairs feedback-based learning in PD, discounting an alternative explanation that warranted consideration.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
</country>
</list>
<tree><country name="Canada"><noRegion><name sortKey="Vo, Andrew" sort="Vo, Andrew" uniqKey="Vo A" first="Andrew" last="Vo">Andrew Vo</name>
</noRegion>
<name sortKey="Hiebert, Nole M" sort="Hiebert, Nole M" uniqKey="Hiebert N" first="Nole M" last="Hiebert">Nole M. Hiebert</name>
<name sortKey="Macdonald, Penny A" sort="Macdonald, Penny A" uniqKey="Macdonald P" first="Penny A" last="Macdonald">Penny A. Macdonald</name>
<name sortKey="Partridge, Allison" sort="Partridge, Allison" uniqKey="Partridge A" first="Allison" last="Partridge">Allison Partridge</name>
<name sortKey="Seergobin, Ken N" sort="Seergobin, Ken N" uniqKey="Seergobin K" first="Ken N" last="Seergobin">Ken N. Seergobin</name>
<name sortKey="Solcz, Stephanie" sort="Solcz, Stephanie" uniqKey="Solcz S" first="Stephanie" last="Solcz">Stephanie Solcz</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A86 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A86 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:25324767
   |texte=   Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25324767" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a ParkinsonCanadaV1

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

La maladie de Parkinson au Canada (serveur d'exploration)

Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease.

Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.